The Vinogradov Laboratory

Department of Psychiatry, University of Minnesota



COTES Community-Based

Cognitive Training




What is the COTES study?


COTES is a research study being conducted by Sophia Vinogradov, M.D. and Rachel Loewy Ph.D about how computerized training might help people with recent-onset schizophrenia lessen their symptoms and learn new thinking and problem-solving skills, and improve their overall quality of life.


Where is the COTES Study?


The COTES study will be run out of three Bay Area Prevention and Recovery in Early Psychosis (PREP) community sites, located in San Francisco, Alameda, and San Mateo, with some parts of the study taking place at the San Francisco Veterans Affairs Medical Center.  However, the participants assigned to the computer training conditions will complete these from their own homes.


Who Can Participate?


Study participants should:

• Have a diagnosis of schizophrenia, schizophreniform, or schizoaffective


• Have had their first psychotic episode within the last 3 years

• Be in good general health

• Be an outpatient (for at least 1 month)

• Not currently be treated with benztropine, diphenhydramine, or high doses

   of clozapine (>500 mg po qd) or olanzapine (>20 mg).

• Use English as their first language

• Be between the ages of 18 and 35 years old

• Be currently enrolled in PREP services and have reached the “stabilization”

   phase of treatment


Why Participate in COTES?

Although you may or may not directly benefit from participating in this research, the information that you provide will help health professionals better understand how computerized training might be used in the future to help people with schizophrenia lessen their symptoms and to learn new thinking skills and problem-solving abilities.


Altogether, you could receive up to $420 for participating in this study! You’ll be paid up to $120 for completing the tests at the start of the study.  After completing the training, you’ll receive up to $150 for the next set of tests, and an additional $150 for the follow-up tests which will be completed 6 months later.



What will happen if I decide to participate?


• Research staff will interview you and give you some tests that include

   questions about your symptoms and how you are feeling, as well as

   some paper and pencil and computerized tests of your thinking.

• You will be assigned by chance to either complete either one of two

   computer-based trainings at home or receive PREP services as usual

   for the next six weeks.  If you are assigned to the computer-based

   training, you’ll be asked to spend 60 minutes per day, five days per

   week,completing a computerized training program at home on a laptop

   the study staff will provide.

• After six weeks, you’ll complete another round of tests about your

   symptoms, your thinking, and how you are feeling.

• You will be asked to return after another 6 moths for some follow-up


• If you were assigned to receive PREP services as usual, you will be

  offered the computerized training after completing the 6 month follow-up




How long will the study take?


If you decide to participate in this study, you will be actively involved in the research study for approximately 8 weeks, with follow-up appointments 6 months after completion.



Contact Information


If you have any questions about participating in the COTES study, please give us a call at (415) 476-7057


                                            Vinogradov Research Lab

                                                      Department of Psychiatry, University of Minnesota

*This study is based out of the University of California, San Francisco Department of Psychiatry*