The Vinogradov Laboratory

Department of Psychiatry, University of Minnesota



Our Research Focus

Sophia Vinogradov, M.D

Principal Investigator


Professor and Department Head

Donald W. Hastings Endowed Chair

Department of Psychiatry


University of Minnesota

For the past 10 years, our research has focused on the design, implementation, and evaluation of neuroscience-informed computerized cognitive training exercises that target the cognitive deficits of schizophrenia.  For example, we have shown that 50 hours (10 weeks) of training of basic auditory processing and auditory/verbal working memory results in significant improvements in untrained measures of verbal learning and memory and general cognition in adults with schizophrenia.  We have also shown that this form of training is associated with quality of life improvements months after training is completed; and that it “normalizes” brain activation patterns during basic auditory processing as well as higher-order complex cognitions. We have investigated serum biomarkers associated with the intervention and have demonstrated that medication-induced anticholinergic burden adversely affects patients’ cognitive gains after training. Though in its early stages, this work is paving the way for an entirely new treatment approach for schizophrenia and other neuropsychiatric illnesses.

If you or a loved one is interested in our cognitive training studies, click here...

For reprints of recent scientific papers, click here....

To access our website about our clinical programs for younger patients, click here...

For general information about schizophrenia, click here...

For information about the Entertainment Software and Cognitive Neurotherapeutics Society meeting, click here...

In the News

Recent Updates

                                            Vinogradov Research Lab

                                                      Department of Psychiatry, University of Minnesota

We have a new research study we've just started!


Interested in taking part in our new remote training  study? Click here

University of Minnesota Looks to Build Top Psychiatric Unit


See the full announcement here!

The Worst Part of Schizophrenia isn't What You Think

By Peter Aldhous


Useful Resources